Monday, May 8, 2017

Is talking to yourself a sign of mental illness? An expert delivers her verdict

Being caught talking to yourself, especially if using your own name in the conversation, is beyond embarrassing. And it’s no wonder – it makes you look like you are hallucinating. Clearly, this is because the entire purpose of talking aloud is to communicate with others. But given that so many of us do talk to ourselves, could it be normal after all – or perhaps even healthy?

The Conversation
We actually talk to ourselves silently all the time. I don’t just mean the odd “where are my keys?” comment – we actually often engage in deep, transcendental conversations at 3am with nobody else but our own thoughts to answer back. This inner talk is very healthy indeed, having a special role in keeping our minds fit. It helps us organise our thoughts, plan actions, consolidate memory and modulate emotions. In other words, it helps us control ourselves.

Talking out loud can be an extension of this silent inner talk, caused when a certain motor command is triggered involuntarily. The Swiss psychologist Jean Piaget observed that toddlers begin to control their actions as soon as they start developing language. When approaching a hot surface, the toddler will typically say “hot, hot” out loud and move away. This kind of behaviour can continue into adulthood.

Non-human primates obviously don’t talk to themselves but have been found to control their actions by activating goals in a type of memory that is specific to the task. If the task is visual, such as matching bananas, a monkey activates a different area of the prefrontal cortex than when matching voices in an auditory task. But when humans are tested in a similar manner, they seem to activate the same areas regardless of the type of task.

Macaque matching bananas. José Reynaldo da Fonseca/wikipedia, CC BY-SA

In a fascinating study, researchers found that our brains can operate much like those of monkeys if we just stop talking to ourselves – whether it is silently or out loud. In the experiment, the researchers asked participants to repeat meaningless sounds out loud (“blah-blah-blah”) while performing visual and sound tasks. Because we cannot say two things at the same time, muttering these sounds made participants unable to tell themselves what to do in each task. Under these circumstances, humans behaved like monkeys do, activating separate visual and sound areas of the brain for each task.
This study elegantly showed that talking to ourselves is probably not the only way to control our behaviour, but it is the one that we prefer and use by default. But this doesn’t mean that we can always control what we say. Indeed, there are many situations in which our inner talk can become problematic. When talking to ourselves at 3am, we typically really try to stop thinking so we can go back to sleep. But telling yourself not to think only sends your mind wandering, activating all kinds of thoughts – including inner talk – in an almost random way.

This kind of mental activation is very difficult to control, but seems to be suppressed when we focus on something with a purpose. Reading a book, for example, should be able to suppress inner talk in a quite efficient way, making it a favourite activity to relax our minds before falling asleep.

A mind-wandering rant could be seen as mad. Dmytro Zinkevych/Shutterstock

But researchers have found that patients suffering from anxiety or depression activate these “random” thoughts even when they are trying to perform some unrelated task. Our mental health seems to depend on both our ability to activate thoughts relevant to the current task and to suppress the
irrelevant ones – mental noise. Not surprisingly, several clinical techniques, such as mindfulness, aim to declutter the mind and reduce stress. When mind wandering becomes completely out of control, we enter a dreamlike state displaying incoherent and context-inappropriate talk that could be described as mental illness.

Loud vs silent chat

So your inner talk helps to organise your thoughts and flexibly adapt them to changing demands, but is there anything special about talking out loud? Why not just keep it to yourself, if there is nobody else to hear your words?

In a recent experiment in our laboratory at Bangor University, Alexander Kirkham and I demonstrated that talking out loud actually improves control over a task, above and beyond what is achieved by inner speech. We gave 28 participants a set of written instructions, and asked to read them either silently or out loud. We measured participants’ concentration and performance on the tasks, and both were improved when task instructions had been read aloud.

Much of this benefit appears to come from simply hearing oneself, as auditory commands seem to be better controllers of behaviour than written ones. Our results demonstrated that, even if we talk to ourselves to gain control during challenging tasks, performance substantially improves when we do it out loud.

This can probably help explain why so many sports professionals, such as tennis players, frequently talk to themselves during competitions, often at crucial points in a game, saying things like “Come on!” to help them stay focused. Our ability to generate explicit self instructions is actually one of the best tools we have for cognitive control, and it simply works better when said aloud.

So there you have it. Talking out loud, when the mind is not wandering, could actually be a sign of high cognitive functioning. Rather than being mentally ill, it can make you intellectually more competent. The stereotype of the mad scientist talking to themselves, lost in their own inner world, might reflect the reality of a genius who uses all the means at their disposal to increase their brain power.

Paloma Mari-Beffa, Senior Lecturer in Neuropsychology and Cognitive Psychology, Bangor University
This article was originally published on The Conversation.

Sunday, May 7, 2017

3 Bible passages to encourage you to keep fighting the good fight of faith when you feel tempted to give up

The Word of God encourages us to fight the good fight of faith and not give up most especially when we are tempted to.

No matter how hard it is to remain faithful to the Lord in the face of trial, temptation, hardship and persecution, we are assured that everything we do for God will never be ignored, unnoticed, and unrewarded.

To encourage you to stand strong in the Lord and keep fighting the good fight of faith even when you're tired and weary from it all, here are a few passages in the Bible. God bless you!

Our Efforts are Seen and will be Rewarded – Hebrews 6:9-12
"But, beloved, we are confident of better things concerning you, yes, things that accompany salvation, though we speak in this manner. For God is not unjust to forget your work and labor of love which you have shown toward His name, in that you have ministered to the saints, and do minister. And we desire that each one of you show the same diligence to the full assurance of hope until the end, that you do not become sluggish, but imitate those who through faith and patience inherit the promises."
 
God's Love will Never be Taken Away from Us – Romans 8:31-39
"What then shall we say to these things? If God is for us, who can be against us? He who did not spare His own Son, but delivered Him up for us all, how shall He not with Him also freely give us all things? Who shall bring a charge against God's elect? It is God who justifies. Who is he who condemns? It is Christ who died, yes, who is risen, who is also at the right hand of God, who also intercedes for us. Who shall separate us from the love of Christ? Shall tribulation, or distress, or persecution, or famine, or nakedness, or peril, or sword? As it is written: "For Your sake we are killed all day long; we are counted as sheep for the slaughter." No, in all these things we are more than conquerors through Him who loved us. For I am persuaded that neither death nor life, neither angels nor principalities nor powers, neither things present nor things to come, neither height nor depth, nor any other created thing, shall be able to separate us from the love of God, which is in Christ Jesus our Lord."

We Shall Reap the Fruit of All of Our Actions – Galatians 6:7-10
"Be not deceived. God is not mocked. For whatever a man sows, that will he also reap. For the one who sows to his own flesh will from the flesh reap corruption, but the one who sows to the Spirit will from the Spirit reap eternal life. And let us not grow weary in doing good, for in due season we shall reap, if we do not give up. Therefore, as we have opportunity, let us do good to all people, especially to those who are of the household of faith."
Source

4 Kind Phrases That Will Empower A Child Forever

Parents, grandparents and any other adult that’s part of a child’s life has a huge impact on shaping that child. Children mimic the behavior that they see. They learn from watching the adults around them. The way you speak and the way you act can have a powerful influence on the little ones around you. Choosing to be a positive influence means setting a good example through your words and through your actions. Your words have a much stronger impact on your child that you realize.



Here are four kind phrases that can change a child’s life forever:

1. “Treat Others As You Want To Be Treated”

Ah, the Golden Rule. Teaching a child about the Golden Rule at a young age can help them understand how important it is to treat others with kindness and respect. Too many people lack the ability to accept others for who they are and treat them with respect. As an adult, your words and actions should show your child that you practice what you preach. If you treat others with kindness and respect, your child will begin to understand. Instead of being a bully or looking down on others, they’ll be a peacemaker and a leader.

2. “Listen Before Speaking”

This lesson might take a few years for a young child to learn, but it’s worth teaching. Being an active listener can help your child in all aspects in life. It will help them be a better student, a better teacher and a better friend. Active listening by concentrating, understanding and responding isn’t always easy. Gently remind your child to listen before speaking, to teach them the importance of respectful communication.

3. “Think Positive Thoughts”

This simple phrase can end up being a powerful lesson. Keeping a positive attitude can be extremely difficult, especially as you get older and life starts to happen. If your child learns to keep a positive attitude when they’re young, even when things are difficult, this lesson will stay with them throughout their adult life.

4. “Kindness Is The Greatest Gift You Can Give”

One of the greatest lessons you can teach your child is to be kind. In a world full of people who are judgmental and lack compassion, finding someone who is genuinely kind and compassionate can be tough. Teach your child how important it is to show kindness to others in any circumstance. One kind act can make a world of difference in someone else’s life.
 

Tuesday, May 2, 2017

What elephants teach us about cancer prevention

Every time a cell divides, there is a chance for a mutation (mistake) to occur in the DNA - the substance that carries genetic information in all living organisms. These mutations can lead to cancer.

The Conversation
If all cells have a similar chance of developing cancer-causing mutations, then very large and long-lived animals with more cells undergoing more cell divisions should develop cancer at a higher rate than smaller, short-lived animals with fewer cells dividing over less time.

But in 1977, Sir Richard Peto noted that humans develop cancer at a rate similar to mice. This is despite having 1,000 times as many cells and living 30 times as long. Another example of this phenomenon can be found in elephants. They are 100 times larger than people and can live 60 to 70 years, and yet, their cancer rates are exceedingly low.

Peto proposed that evolutionary considerations might explain the differences in per-cell cancer incidence across species. When comparing cancer rates in mice and men, he proposed that as humans evolved to grow larger and live longer throughout evolutionary history – with more human cells dividing over a longer period of time – that they also evolved to resist cancer. This surprising cancer resistance found in larger, long-lived animals, like elephants, has become known as Peto’s Paradox.
Our research team provided the first empirical data documenting cancer across species in support of Peto’s Paradox.

We showed that cancer mortality does not increase with body size or life span. Actually, we observed that some larger, longer living animals may develop less cancer. We calculated elephant cancer mortality rates at less than 5%, compared to human cancer mortality rates of 11% to 25%.
Elephants have had 55 million years of development to figure out how to resist cancer, and we hope that we can one day apply these lessons to develop effective treatments for cancer.

Cancer resistance

Our team looked at the genome of the African elephant for changes in oncogenes and tumour suppressor genes. Oncogenes can cause cells to grow out of control while tumour suppressor genes slow down cell division. These are the two main types of genes that play a role in cancer and could help explain potential mechanisms of cancer resistance in elephants.

Our analysis revealed the shocking discovery that elephants express many extra genes derived from the critical tumour suppressor gene TP53.

TP53 is called the “Guardian of the Genome” due to its ability to protect cells from accumulating cancer causing mutations. The TP53 gene responds to DNA damage, or pre-cancer, by stopping the cell from dividing until the DNA can be repaired. If the cell cannot fix the DNA, then TP53 causes the cell to die through a process called apoptosis. Sacrificing damaged cells prevents the propagation of cells with mutations that could lead to cancer.

People with Li-Fraumeni Syndrome have a mutation in one copy of their TP53 genes, with more than 90% lifetime risk to develop cancer. This high rate of cancer associated with TP53 dysfunction illustrates the critical role that TP53 plays in protecting us from cancer.

Naturally cancer resistant

Our lab at the University of Utah studies the broken DNA damage response in people with Li-Fraumeni Syndrome who are missing their TP53 genes and have a very high rate of cancer.
When we learned that elephants were naturally cancer resistant and also had 20 times as much TP53 as humans (40 gene copies total in elephants vs. 2 gene copies in healthy humans), we teamed up with Dr. Carlo Maley, an evolutionary and cancer biologist who helped to make the initial discovery about extra elephant TP53.

We used our clinical and research experience from studying patients with Li-Fraumeni Syndrome to try to understand if elephant TP53 could be playing a role in protecting elephants from cancer. Because we already were measuring TP53 function in people with and without Li-Fraumeni Syndrome, we could use the same laboratory tests to measure how elephant cells responded to DNA damage.

To perform these experiments, we collaborated closely with Utah’s Hogle Zoo (who have African elephants) as well as Ringling Bros. and Barnum Bailey Circus (who have Asian elephants). Both groups routinely draw blood from their elephants to monitor their health, and we received approval to study the blood when it was drawn for these routine elephant health screening procedures.

The blood was sent to our lab where the white blood cells, called lymphocytes, were exposed to ionising radiation to induce DNA breakage. We monitored how quickly broken DNA was repaired in the African and Asian elephant lymphocytes compared to human lymphocytes.

We predicted that elephant cells would repair their DNA faster than human cells, but discovered that the rate of DNA repair was similar between elephant and human cells. But we noticed something interesting about the elephant cells after it was exposed to radiation: more elephant cells than human cells underwent programmed cell death or apoptosis.

We next undertook rigorous experiments to compare the percent of elephant cells vs. human cells vs. Li-Fraumeni Syndrome cells that died from DNA damage, or pre-cancer.

We discovered that the amount of apoptosis correlated with the number of TP53 genes and that this followed the same pattern of lifetime cancer risk – elephants (~5%), humans (~50%), patients with LFS (~90%). This makes sense because more TP53 makes the cell more effective at removing pre-cancer cells that could go on to form cancer.

Learning from elephants to help people

We showed that elephant TP53 helps elephants to more quickly remove pre-cancerous cells with DNA damage and that this possibly contributes to elephant cancer resistance.

Now, we are focusing our research efforts to better understand the specific mechanism of how elephant TP53 works. The ultimate goal of our laboratory work is to help patients who already have cancer, and maybe even those people who could be at risk for cancer in the future.
We want to see if we can translate this fascinating discovery into an effective treatment for cancer, or maybe even potentially as a cancer prevention strategy. In the end, we are working to create a world with more elephants and less cancer.

Joshua Schiffman, Professor of Pediatrics, University of Utah and Lisa Abegglen, Pediatrics - Visiting Instructor, University of Utah
This article was originally published on The Conversation.